Levocarnitine

Levocarnitine

30 ml

“In a 2003 meta-analysis of 21 clinical trials, a total of 1,204 adults with mild cognitive impairment or mild Alzheimer’s disease took supplements containing 1.5 g to 3.0 g/day acetyl-L-carnitine or placebo for 3 to 12 months. Clinical and psychometric assessment scores were better, and improvements determined by clinicians were greater in supplement users than in the placebo groups.”

Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer’s disease. Int Clin Psychopharmacol 2003;18:61-71

“Carnitine plays a role in transporting long-chain fatty acids in the myocardial mitochondria, where they are metabolized via oxidation for energy. It is also involved in moderating oxidative stress and might decrease markers of inflammation. During ischemic events, carnitine prevents fatty acid ester accumulation, which can lead to fatal ventricular arrhythmias. For these reasons, researchers are examining whether carnitine affects cardiovascular health.”

DiNicolantonio JJ, Lavie CJ, Fares H, Menezes AR, O’Keefe JH. L-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis. Mayo Clin Proc 2013;88:544-51

“A 2023 meta-analysis of 41 randomized clinical trials examined the effects of L-carnitine supplementation on glycemic markers in 2,900 men and women aged 18 years and older. Most participants had health conditions such as type 2 diabetes, obesity, polycystic ovary syndrome, or non-alcoholic fatty liver disease. L-carnitine supplements at doses of 0.25 to 4 g/day for 2 to 52 weeks reduced fasting blood glucose, insulin resistance, and glycosylated hemoglobin (HbA1c), but not serum insulin levels.”

Zamani M, Pahlavani N, Nikbaf-Shandiz M, Rasaei N, Ghaffarian-Ensaf R, et al. The effects of L-carnitine supplementation on glycemic markers in adults: A systematic review and dose-response meta-analysis. Front Nutr. 2023 Jan 10;9:1082097

“A systematic review and meta-analysis of three randomized clinical trials examined the effects of 1 g/day to 3 g/day L-carnitine or acetyl-L- -carnitine for 2 to 6 months on sperm parameters in 201 men aged 20 to 40 years who had infertility. Compared to placebo, supplemental carnitine improved sperm motility by 7.84% and morphology by 4.91% but did not affect sperm concentration.”

Salas-Huetos A, Rosique-Esteban N, Becerra-Tomás N, Vizmanos B, Bulló M, et al. The effect of nutrients and dietary supplements on sperm quality parameters: a systematic review and meta-analysis of randomized clinical trials. Adv Nutr 2018;9:833-48.

“Carnitine helps preserve muscle glycogen and promote fat oxidation. It also spares the use of amino acids as energy sources during exercise, making them potentially available for new protein synthesis.”

Gnoni A, Longo S, Gnoni GV, Giudetti AM. Carnitine in human muscle bioenergetics: Can carnitine supplementation improve physical exercise?
Molecules 2020;25:182.